Absence of TERT promoter mutations in colorectal precursor lesions and cancer
- PMID: 29473934
- PMCID: PMC5901499
- DOI: 10.1590/1678-4685-GMB-2017-0133
Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Abstract
Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian patients, including 103 subjects with precursor lesions and 42 with colorectal carcinomas, and we associated the presence of such mutations with the patients clinical-pathological features. The mutation analysis was conclusive in 123 cases, and none of the precursor and colorectal carcinoma cases showed TERT promoter mutations. We conclude that TERT mutations are not a driving factor in colorectal carcinogenesis.
Figures
Similar articles
-
Telomerase reverse transcriptase promoter mutations in glandular lesions of the urinary bladder.Ann Diagn Pathol. 2015 Oct;19(5):301-5. doi: 10.1016/j.anndiagpath.2015.06.007. Epub 2015 Jun 16. Ann Diagn Pathol. 2015. PMID: 26239299
-
Identification of somatic TERT promoter mutations in familial nonmedullary thyroid carcinomas.Clin Endocrinol (Oxf). 2017 Oct;87(4):394-399. doi: 10.1111/cen.13375. Epub 2017 Jun 19. Clin Endocrinol (Oxf). 2017. PMID: 28502101
-
Frequency of TERT Promoter Mutations in Prostate Cancer.Pathobiology. 2015;82(2):53-7. doi: 10.1159/000381903. Epub 2015 May 21. Pathobiology. 2015. PMID: 25997473
-
TERT promoter mutations in thyroid cancer.Endocr Relat Cancer. 2016 Mar;23(3):R143-55. doi: 10.1530/ERC-15-0533. Epub 2016 Jan 5. Endocr Relat Cancer. 2016. PMID: 26733501 Free PMC article. Review.
-
Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma.Infect Agent Cancer. 2017 May 19;12:27. doi: 10.1186/s13027-017-0138-5. eCollection 2017. Infect Agent Cancer. 2017. PMID: 28529542 Free PMC article. Review.
Cited by
-
Clinically Uncertain Liver Masses: A Guide to Distinguishing Poorly Differentiated Primary Liver Cancer.Biomedicines. 2025 Apr 28;13(5):1063. doi: 10.3390/biomedicines13051063. Biomedicines. 2025. PMID: 40426891 Free PMC article.
-
Somatic targeted mutation profiling of colorectal cancer precursor lesions.BMC Med Genomics. 2022 Jun 28;15(1):143. doi: 10.1186/s12920-022-01294-w. BMC Med Genomics. 2022. PMID: 35761395 Free PMC article.
-
Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers.Cancer Discov. 2024 Oct 4;14(10):1940-1963. doi: 10.1158/2159-8290.CD-23-1379. Cancer Discov. 2024. PMID: 38885349 Free PMC article.
-
Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing.JNCI Cancer Spectr. 2019 Apr 16;3(2):pkz012. doi: 10.1093/jncics/pkz012. eCollection 2019 Jun. JNCI Cancer Spectr. 2019. PMID: 31360895 Free PMC article.
References
-
- Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, de Almeida GC, Matsushita MM, et al. The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism. Int J Cancer. 2016;139:414–423. - PubMed
-
- Cesare AJ, Reddel RR. Alternative lengthening of telomeres: Models, mechanisms and implications. Nat Rev Genet. 2010;11:319–330. - PubMed
-
- Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759–767. - PubMed
-
- Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–E386. - PubMed
-
- Goss PE, Lee BL, Badovinac-Crnjevic T, Strasser-Weippl K, Chavarri-Guerra Y, St Louis J, Villarreal-Garza C, Unger-Saldana K, Ferreyra M, Debiasi M, et al. Planning cancer control in Latin America and the Caribbean. Lancet Oncol. 2013;14:391–436. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources