Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters

Melissa M Smarr¹, Masato Honda², Kurunthachalam Kannan³, Zhen Chen⁴, Sungduk Kim⁵, Germaine M Buck Louis⁶

Affiliations

¹ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA; Department of Environmental Health, Rollins School of Public Health of Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA. Electronic address: melissa.smarr@emory.edu.
² Wadsworth Center, New York State Department of Health, Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, NY 12201, USA. Electronic address: Masato.Honda@health.ny.gov.
³ Wadsworth Center, New York State Department of Health, Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, NY 12201, USA. Electronic address: kurunthachalam.kannan@health.ny.gov.
⁴ Biostatistic and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA. Electronic address: chenzhe@mail.nih.gov.
⁵ Biostatistic and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA; Biostatistics Branch, Division of Cancer Epidemiology and Genetic, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr, Rockville, MD 20850, USA. Electronic address: kims2@mail.nih.gov.
⁶ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA; Dean's Office, College of Health and Human Services, George Mason University, 4400 University Ave., Fairfax, VA 22030, USA. Electronic address: glouis@gmu.edu.

PMID: 29474822
PMCID: PMC5878147
DOI: 10.1016/j.reprotox.2018.02.008

Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters

Melissa M Smarr et al. Reprod Toxicol. 2018 Apr.

. 2018 Apr:77:103-108.

doi: 10.1016/j.reprotox.2018.02.008. Epub 2018 Feb 21.

Authors

Melissa M Smarr¹, Masato Honda², Kurunthachalam Kannan³, Zhen Chen⁴, Sungduk Kim⁵, Germaine M Buck Louis⁶

Affiliations

¹ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA; Department of Environmental Health, Rollins School of Public Health of Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA. Electronic address: melissa.smarr@emory.edu.
² Wadsworth Center, New York State Department of Health, Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, NY 12201, USA. Electronic address: Masato.Honda@health.ny.gov.
³ Wadsworth Center, New York State Department of Health, Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, NY 12201, USA. Electronic address: kurunthachalam.kannan@health.ny.gov.
⁴ Biostatistic and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA. Electronic address: chenzhe@mail.nih.gov.
⁵ Biostatistic and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA; Biostatistics Branch, Division of Cancer Epidemiology and Genetic, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr, Rockville, MD 20850, USA. Electronic address: kims2@mail.nih.gov.
⁶ Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20829, USA; Dean's Office, College of Health and Human Services, George Mason University, 4400 University Ave., Fairfax, VA 22030, USA. Electronic address: glouis@gmu.edu.

PMID: 29474822
PMCID: PMC5878147
DOI: 10.1016/j.reprotox.2018.02.008

Abstract

Antimicrobials including parabens, triclosan, and triclocarban have endocrine disrupting properties. Among 501 male partners of couples planning to become pregnant, preconception urinary biomarkers of parabens, triclosan and triclocarban exposure were quantified in spot urine samples. Men also provided two fresh semen samples collected approximately one month to undergo 24-h semen quality analysis. Linear mixed-effects models, adjusted for creatinine, race, age and body mass index, were utilized to assess the relationship between log transformed chemical concentrations rescaled by their standard deviations and semen parameters. Methyl, ethyl and butyl parabens, were associated with diminished sperm count and several sperm motility parameters. Hydroxylated paraben metabolites and triclosan were significantly positively associated with select semen quality parameters. Overall, our findings suggest that specific urinary parabens found in consumer goods (methyl, ethyl and butyl parabens) may adversely impact sperm quality parameters among reproductive-age male partners of couples trying for pregnancy.

Keywords: Antimicrobials; Parabens; Semen quality; Triclocarban; Triclosan.

Published by Elsevier Inc.

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Conflict of interest statement

Competing Financial Interests: The authors declare they have no actual or potential competing financial interests.

References

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Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters

Affiliations

Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources