Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Mar;93(3):535-537.
doi: 10.1016/j.kint.2017.09.032.

Claudins: a tale of interactions in the thick ascending limb

Eric Olinger  1 , Pascal Houillier  2 , Olivier Devuyst  3
Affiliations
Free article
Comment

Claudins: a tale of interactions in the thick ascending limb

Eric Olinger et al. Kidney Int. 2018 Mar.
Free article

Abstract

The claudins are the main proteins composing the tight junctions. The differential expression of claudin isoforms contributes to the specificity of paracellular transport pathways along the kidney tubule. Recent studies focusing on claudin-10 and claudin-16 support the longitudinal specialization of paracellular transport of cations within the thick ascending limb and demonstrate that complex tubular adaptations operate to buffer the consequences of chronic segmental lesions in the kidney.

PubMed Disclaimer

Comment on

LinkOut - more resources