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Case Reports
. 2018 Apr;57(2):222-224.
doi: 10.1016/j.transci.2018.02.003. Epub 2018 Feb 9.

Dasatinib-induced immune mediated-thrombotic thrombocytopenic purpura

Esra Terzi Demirsoy  1 , Ozgur Mehtap  2 , Elif Birtas Atesoglu  2 , Pinar Tarkun  2 , Necmi Eren  3 , Ayfer Gedük  2 , Abdullah Hacihanefioglu  2
Affiliations
Case Reports

Dasatinib-induced immune mediated-thrombotic thrombocytopenic purpura

Esra Terzi Demirsoy et al. Transfus Apher Sci. 2018 Apr.

Abstract

Most commonly seen side effects with Tyrosine kinase inhibitors (TKI's) are hematologic toxicities. Besides, with dasatinib autoimmune side effects can be seen. Thrombotic thrombocytopenic purpura (TTP) is a life- threatening disease that can be related to various causes mainly autoimmune disorders or antineoplastic drugs. Few cases of TKI associated secondary thrombotic microangiopathies (TMA) have been reported in literature. Most of cases were diagnosed as hemolytic uremic syndrome (HUS) rather than TTP. Herein, we describe a 37-year-old CML patient who was diagnosed as immune-mediated TTP related to dasatinib.

Keywords: Dasatinib; Plasma exchange; Side effect; Thrombotic thromboytopenic purpura.

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