Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Mar 6;115(10):2272-2274.
doi: 10.1073/pnas.1800448115. Epub 2018 Feb 23.

Neutrophils in hot pursuit of MRSA in the lymph nodes

Lloyd S Miller  1   2   3   4 , Scott I Simon  5
Affiliations
Comment

Neutrophils in hot pursuit of MRSA in the lymph nodes

Lloyd S Miller et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: L.S.M. reports grant support from MedImmune, Regeneron Pharmaceuticals, Moderna Therapeutics, and Pfizer, which are developing therapeutics and vaccines against Staphylococcus aureus and other pathogens.

Figures

Fig. 1.
Fig. 1.
Neutrophil recruitment and clearance of S. aureus in draining lymph nodes. (A) S. aureus bacteria travel in afferent lymphatics from the initial footpad infection to the popliteal lymph node. (B) Neutrophils are recruited to lymph nodes through HEVs to promote bacterial clearance and prevent systemic bacterial dissemination. (C) Mechanisms in lymph node HEVs that facilitate neutrophil tethering, rolling, adhering, and migration into the lymph nodes.
See this image and copyright information in PMC

Comment on

References

    1. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375:1557–1568. - PMC - PubMed
    1. Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG., Jr Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28:603–661. - PMC - PubMed
    1. Bogoslowski A, Butcher EC, Kubes P. Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus. Proc Natl Acad Sci USA. 2018;115:2449–2454. - PMC - PubMed
    1. Chtanova T, et al. Dynamics of neutrophil migration in lymph nodes during infection. Immunity. 2008;29:487–496. - PMC - PubMed
    1. Abadie V, et al. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood. 2005;106:1843–1850. - PubMed

Publication types

LinkOut - more resources