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. 2018 Feb 23;8(1):3528.
doi: 10.1038/s41598-018-21913-w.

Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats

Jie Yu  1 , Jing Yang  1 , Mizhuan Li  1 , Xuesong Yang  1 , Pan Wang  2 , Jie Xu  3
Affiliations

Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats

Jie Yu et al. Sci Rep. .

Abstract

The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague-Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH-group), HSHFD + green tea (0.24 g/kg/day) (TH-group), HSHFD + low-dose zinc selenium organic tea (0.24 g/kg/day) (ZTHL-group), and HSHFD + high-dose zinc selenium organic tea (1.20 g/kg/day) (ZTHH-group). After 8 weeks, compared to both the C-group and CH-group, the hepatosomatic index (HI) was significantly reduced in the ZTHL-group (p < 0.05). Fasting blood glucose (FBG) levels were highest in the TH-group, followed by the CH-group, then the ZTHL-group, then the ZTHH-group, and finally the C-group. Compared with the CH-group, the serum total cholesterol (TC) and low density lipid-cholesterol (LDL-C) concentrations were significantly lower in the ZTHH-group (p < 0.05). Significant decreases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acids (TBA), alkaline phosphatase (ALP), and direct bilirubin (DBIL) levels were observed in ZTHL-group versus the CH-group (p < 0.05). Serum alpha-L-fucosidase (AFU) levels in the ZTHH-group were lower than in the CH-group (P < 0.01). Histopathological examination of the liver and fat biopsies illustrates that the liver cells showed a decrease in the extent of necrosis and dropsy in the ZTHL-group and ZTHH-group versus the CH-group. Zinc selenium tea showed a protection effect against hepatic damage.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Exposure flow chart. (ND: normal-diet, HSHF: high-sucrose-high-fat diet, W: week).
Figure 2
Figure 2
Effect of zinc selenium tea on the body weight in experimental groups (g, mean and SEM, n = 10).
Figure 3
Figure 3
Effect of zinc selenium tea on hepatosomatic index (%, n = 10, mean and SEM) in experimental groups. aVs C-group, p < 0.05; bvs CH-group, p < 0.05.
Figure 4
Figure 4
Effect of zinc selenium tea on fat index (%, n = 10, mean and SEM) in experimental groups. aVs C-group, p < 0.05; bvs CH-group, p < 0.05.
Figure 5
Figure 5
Effect of zinc selenium tea on OGTT in experimental groups (mean and SEM). SEM bars are small and contained within the symbol in the figure.
Figure 6
Figure 6
Glucose area under the curve during oral glucose tolerance test (OGTT) (n = 10, mean and SEM). aVs C-group, p < 0.05; bvs CH-group, p < 0.05; cvs TH-group.
Figure 7
Figure 7
Effect of zinc selenium tea on serum TC, TG, HDL-C, and LDL-C concentrations (n = 10, mean and SEM) in experimental groups. aVs C-group, p < 0.05; bvs CH-group, p < 0.05.
Figure 8
Figure 8
Effect of zinc selenium tea on ALT and AST activities in serum (n = 10, mean and SEM) in experimental groups. aVs C-group, p < 0.05; bvs CH-group, p < 0.05.
Figure 9
Figure 9
The histological features of liver in experimental rats (400×). Liver tissues from SD rats were stained with hematoxylin and eosin. Arrow: dropsy, necrosis, and disorder of liver cells.
Figure 10
Figure 10
The histological features of adipose tissue in experimental rats (400×). Fat tissue of SD rats was stained with hematoxylin and eosin. Arrow: adipocyte incorporation.
Figure 11
Figure 11
Comparison in the number of adipocyte in different treatment groups in histological examination. aVs C-group, p < 0.05; bvs CH-group, p < 0.05; cvs TH-group, p < 0.05.
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