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Comment
. 2018 Mar;20(3):228-230.
doi: 10.1038/s41556-018-0049-8.

Size matters in nanoscale communication

Andries Zijlstra  1   2 , Dolores Di Vizio  3   4   5
Affiliations
Comment

Size matters in nanoscale communication

Andries Zijlstra et al. Nat Cell Biol. 2018 Mar.

Abstract

Exosomes are heterogeneous, nanoscale vesicles that mediate cellular communication. A study now leverages a size separation strategy to identify sub-classes of nanoparticles. Besides revealing a subtype without an encapsulating membrane, biochemical analyses show variation in vesicle cargo, suggesting that size is not the only driver of heterogeneity.

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Figures

Figure 1.
Figure 1.. Schematic representation of vesicle subpopulations that comprise the cellular communication milieu.
Stratified extracellular vesicles, including the recently identified exomeres, listed according to size ranges. Whereas the biogenesis of exosomes is relatively well-defined, the biogenesis of larger vesicles and exomeres is currently unknown. Extracellular vesicles contain cargo material from the cytoplasm, mitochondria, Golgi, the plasma membrane, endoplasmic reticulum and nucleus. Abbreviations: EV, extracellular vesicle; MVB, multivesicular bodies.
See this image and copyright information in PMC

Comment on

  • Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.
    Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Zhang H, et al. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. Nat Cell Biol. 2018. PMID: 29459780 Free PMC article.

References

    1. Lötvall J et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 3, 26913 (2014). - PMC - PubMed
    1. Peinado H et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883–891 (2012). - PMC - PubMed
    1. van der Vos KE et al. Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain. Neuro. Oncol. 18, 58–69 (2016). - PMC - PubMed
    1. Clancy JW et al. Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Nat. Commun. 6, 6919 (2015). - PMC - PubMed
    1. Sung BH, Ketova T, Hoshino D, Zijlstra A & Weaver AM Directional cell movement through tissues is controlled by exosome secretion. Nat. Commun. 6, 7164 (2015). - PMC - PubMed

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