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Review
. 2018 Sep;20(9):1127-1135.
doi: 10.1007/s12094-018-1848-x. Epub 2018 Feb 23.

Radiotherapy in soft-tissue sarcoma of the extremities

R Correa  1 , J Gómez-Millán  2 , M Lobato  2 , A Fernández  2 , R Ordoñez  2 , C Castro  2 , Y Lupiañez  2 , J A Medina  2
Affiliations
Review

Radiotherapy in soft-tissue sarcoma of the extremities

R Correa et al. Clin Transl Oncol. 2018 Sep.

Abstract

Sarcomas are an infrequent and heterogeneous group of neoplasia. Surgery with or without associated radiotherapy (RT) is the basic treatment for this type of tumour. To increase the therapeutic ratio (the index between cytotoxic effects in tumours and normal tissue complications with a certain dose of radiation), new advances are being investigated to increase local and distant control and to decrease the morbidity of the treatment. The aim of this review was to analyse the different strategies, based on technology and biology, which are being investigated to increase the therapeutic ratio of this disease.

Keywords: Chemotherapy; Conservative surgery; Multikinase inhibitor; Postoperative radiotherapy; Preoperative radiotherapy; Soft-tissue sarcoma.

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