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Comparative Study
. 2018 Mar 1;23(2):e168-e179.
doi: 10.4317/medoral.22155.

Craniomaxillofacial morphology alterations in children, adolescents and adults with neurofibromatosis 1: A cone beam computed tomography analysis of a Brazilian sample

E-B Luna  1 , M-E-R Janini, F Lima, R-R-A Pontes, F-R Guedes, M Geller, L-E da Silva, A-T Motta, K-S Cunha
Affiliations
Comparative Study

Craniomaxillofacial morphology alterations in children, adolescents and adults with neurofibromatosis 1: A cone beam computed tomography analysis of a Brazilian sample

E-B Luna et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Oral manifestations are common in neurofibromatosis 1 (NF1), and include jaws and teeth alterations. Our aim was to investigate the craniomaxillofacial morphology of Brazilian children, adolescents and adults with NF1 using cone beam computed tomography.

Material and methods: This study was conducted with 36 Brazilian individuals with NF1 with ages ranging from 4 to 75. The participants were submitted to anamnesis, extra and intraoral exam and cephalometric analysis using cone beam computed tomography. Height of the NF1 individuals was compared to the length of jaws and skull base. The results of the cephalometric measurements of the NF1 group were compared with a control group paired by age, gender and skin color.

Results: Individuals with NF1 had lower maxillary length (p<0.0001), lower mandibular length (p<0.0001), lower skull base length (p<0.0001). In children and adolescents, the mandible was more posteriorly positioned (p=0.01), when compared with the control group. There was no association between jaws and skull base length with the height of the individuals with NF1.

Conclusions: Brazilian children, adolescents and adults with NF1 have short mandible, maxilla and skull base. Moreover, children and adolescents present mandibular retrusion.

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Conflict of interest statement

Conflict of interest statement: The authors state that they have no conflict of interest.

Figures

Figure 1
Figure 1
Facial clinical aspects of the individuals with neurofibromatosis 1 (patient 1-24) Front (A) and lateral (B) views.
Figure 2
Figure 2
Facial clinical aspects of the individuals with neurofibromatosis 1 (patient 25-36). Front (A) and lateral (B) views.
Figure 3
Figure 3
Measures that had significant differences between the NF1 and control groups. SN: sella-nasion line (skull base length); NB: nasion-B line; SNB: Relationship between the mandible and skull base (sella-nasion-B). ANS-PNS: anterior nasal spine-posterior nasal spine line (maxilla length); Go-Me: gonion-menton line (mandible length).
See this image and copyright information in PMC

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