doi: 10.1016/0009-2797(86)90059-1.
The effect of nicotinamide on N-methyl-N'-nitro-N-nitrosoguanidine induced killing and mutation
- PMID: 2947708
- DOI: 10.1016/0009-2797(86)90059-1
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The effect of nicotinamide on N-methyl-N'-nitro-N-nitrosoguanidine induced killing and mutation
Chem Biol Interact.
1986 Dec.
Abstract
Nicotinamide, an inhibitor of poly(ADP-ribose) synthesis has been found to increase the killing of Chinese hamster V-79 cells induced by N-methyl-N'-nitro-N-nitrosoguanidine in concentration dependent manner. Such treatment also decreased the induced mutation. The nature of the results obtained was similar to those obtained earlier with benzamide, another inhibitor.
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