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Editorial
. 2018 Mar 7;26(3):659-660.
doi: 10.1016/j.ymthe.2018.02.007. Epub 2018 Feb 22.

Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats

Diana Schenkwein  1 , Seppo Ylä-Herttuala  2
Affiliations
Editorial

Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats

Diana Schenkwein et al. Mol Ther. .
No abstract available

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Comment on

  • Correction of a pathogenic gene mutation in human embryos.
    Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Ma H, et al. Nature. 2017 Aug 24;548(7668):413-419. doi: 10.1038/nature23305. Epub 2017 Aug 2. Nature. 2017. PMID: 28783728

References

    1. Ma H., Marti-Gutierrez N., Park S.W., Wu J., Lee Y., Suzuki K., Koski A., Ji D., Hayama T., Ahmed R. Correction of a pathogenic gene mutation in human embryos. Nature. 2017;548:413–419. - PubMed
    1. Tang L., Zeng Y., Du H., Gong M., Peng J., Zhang B., Lei M., Zhao F., Wang W., Li X., Liu J. CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein. Mol. Genet. Genomics. 2017;292:525–533. - PubMed
    1. Kang X., He W., Huang Y., Yu Q., Chen Y. Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing. J. Assist. Reprod. Genet. 2016;33:581–588. - PMC - PubMed
    1. Liang P., Xu Y., Zhang X., Ding C., Huang R., Zhang Z., Lv J., Xie X., Chen Y., Li Y. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell. 2015;6:363–372. - PMC - PubMed
    1. Egli D., Zuccaro M.V., Kosicki M., Church G.M., Bradley A., Jasin M. Inter-homologue repair in fertilized eggs? bioRxiv. 2017 - PubMed

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