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Comment
. 2018 Apr;34(4):255-256.
doi: 10.1016/j.tig.2018.02.004. Epub 2018 Feb 21.

Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells

Zuzana Storchová  1
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Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells

Zuzana Storchová. Trends Genet. 2018 Apr.

Abstract

Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of aneuploid cells depends on sphingolipid homeostasis offers an appealing opportunity for cancer treatment.

Keywords: Aneuploidy; cancer; ceramides; sphingolipids.

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