Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2018 Jul;45(8):1405-1416.
doi: 10.1007/s00259-018-3976-5. Epub 2018 Feb 24.

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Hiroshi Matsuda  1 , Miho Murata  2 , Yohei Mukai  2 , Kazuya Sako  3 , Hidetoshi Ono  4 , Hiroshi Toyama  5 , Yoshitaka Inui  5 , Yasuyuki Taki  6 , Hideo Shimomura  6 , Hiroshi Nagayama  7 , Amane Tateno  8 , Kenjiro Ono  9 , Hidetomo Murakami  9 , Atsushi Kono  10   11 , Shigeki Hirano  12 , Satoshi Kuwabara  12 , Norihide Maikusa  13 , Masayo Ogawa  13 , Etsuko Imabayashi  13 , Noriko Sato  14 , Harumasa Takano  13 , Jun Hatazawa  15 , Ryosuke Takahashi  16
Affiliations
Multicenter Study

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Hiroshi Matsuda et al. Eur J Nucl Med Mol Imaging. 2018 Jul.

Abstract

Purpose: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan.

Methods: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30-83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom.

Results: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30-39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70-79 age group.

Conclusions: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.

Keywords: Dopamine transporter; Multicenter trial; Normal database; SPECT; [123I]FP-CIT.

PubMed Disclaimer

Conflict of interest statement

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Written informed consent was obtained from all individual participants included in the study.

Conflict of interest

H. Matsuda has received a research grant and speaker honorarium from Nihon Medi-Physics Co., Ltd.. M. Murata, K. Sako, H. Toyama, Y. Taki, H. Nagayama, K. Ono, A. Kono, S. Hirano, N. Sato, H. Takano and J. Hatazawa have received research grants from Nihon Medi-Physics Co., Ltd.. Y. Mukai, H. Ono, Y. Inui, H, Shimomura, A. Tateno, H. Murakami, S. Kuwabara, N. Maikusa, M. Ogawa, E. Imabayashi, and R. Takahashi have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
SPECT image of a striatal phantom containing different 123I activity concentrations between striatal compartments and the background. Striatal SBRs were estimated by the Southampton method
Fig. 2
Fig. 2
Measured SBRs of SPECT data of a phantom by the Southampton method plotted against the true SBR from measurements of aliquots by a well counter for the Toshiba GCA9300A (a), Philips Bright View (b), Siemens Symbia T6 (c), and GE Discovery MN/CT 670 (d). The linear regression lines are displayed for each reconstruction condition, namely, ChangACSC, ChangACNOSC, CTACSC, CTACNOSC, and NOACNOSC. Also shown is the line of identity (in gray). Similarly high correlations were also obtained between the measured SBR and true SBR in other SPECT scanners
Fig. 3
Fig. 3
Quantitative SPECT images before and after phantom calibration in a young healthy control under different reconstruction conditions. The original SBRs before calibration ranged widely from 8.75 in NOACNOSC to 15.59 in ChangACSC. In contrast, the calibrated SBRs were almost constant under NOSC conditions and somewhat higher under scatter correction conditions
Fig. 4
Fig. 4
Scatter plot of SBR as a function of age in 510 data from 256 healthy controls of both sexes. Data relevant to the average SBR for the left and right striatum are fitted by a linear regression line with 95% upper and lower confidence interval (CI) and prediction interval (PI) lines
Fig. 5
Fig. 5
Scatter plot of SBR as a function of age in 280 data from 140 women. Data relevant to the average SBR for the left and right striatum are fitted by a linear regression line with 95% upper and lower confidence interval (CI) and prediction interval (PI) lines
Fig. 6
Fig. 6
Scatter plot of SBR as a function of age in 230 data from 116 men. Data relevant to the average SBR for the left and right striatum are fitted by a linear regression line with 95% upper and lower confidence interval (CI) and prediction interval (PI) lines
Fig. 7
Fig. 7
Scatter plot of the asymmetry index (AI) between the right and left striatal SBR as a function of age in 510 data from 256 healthy controls of both sexes. Data relevant to the AI of the striatal SBR are fitted by a linear regression line with a 95% upper prediction interval (PI) line
See this image and copyright information in PMC

References

    1. Booij J, Tissingh G, Boer GJ, Speelman JD, Stoof JC, Janssen AG, et al. [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997;62(2):133–140. doi: 10.1136/jnnp.62.2.133. - DOI - PMC - PubMed
    1. Walker Z, Costa DC, Walker RW, Shaw K, Gacinovic S, Stevens T, et al. Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand. J Neurol Neurosurg Psychiatry. 2002;73(2):134–140. doi: 10.1136/jnnp.73.2.134. - DOI - PMC - PubMed
    1. Albert NL, Unterrainer M, Diemling M, Xiong G, Bartenstein P, Koch W, et al. Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes. Eur J Nucl Med Mol Imaging. 2016;43(7):1315–1322. doi: 10.1007/s00259-015-3304-2. - DOI - PubMed
    1. Söderlund TA, Dickson JC, Prvulovich E, Ben-Haim S, Kemp P, Booij J, et al. Value of semiquantitative analysis for clinical reporting of 123I-2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane SPECT studies. J Nucl Med. 2013;54(5):714–722. doi: 10.2967/jnumed.112.110106. - DOI - PubMed
    1. Meyer PT, Sattler B, Lincke T, Seese A, Sabri O. Investigating dopaminergic neurotransmission with 123I-FP-CIT SPECT: comparability of modern SPECT systems. J Nucl Med. 2003;44(5):839–845. - PubMed

Publication types

Substances