Gene expression: Developmental enhancers in action

Comment

Eytan Zlotorynski. Nat Rev Genet. 2018 Apr.

. 2018 Apr;19(4):187.

doi: 10.1038/nrg.2018.13. Epub 2018 Feb 26.

No abstract available

Comment on

Widespread transcriptional pausing and elongation control at enhancers.
Henriques T, Scruggs BS, Inouye MO, Muse GW, Williams LH, Burkholder AB, Lavender CA, Fargo DC, Adelman K. Henriques T, et al. Genes Dev. 2018 Jan 1;32(1):26-41. doi: 10.1101/gad.309351.117. Epub 2018 Jan 29. Genes Dev. 2018. PMID: 29378787 Free PMC article.
The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription.
Mikhaylichenko O, Bondarenko V, Harnett D, Schor IE, Males M, Viales RR, Furlong EEM. Mikhaylichenko O, et al. Genes Dev. 2018 Jan 1;32(1):42-57. doi: 10.1101/gad.308619.117. Epub 2018 Jan 29. Genes Dev. 2018. PMID: 29378788 Free PMC article.
Enhancer redundancy provides phenotypic robustness in mammalian development.
Osterwalder M, Barozzi I, Tissières V, Fukuda-Yuzawa Y, Mannion BJ, Afzal SY, Lee EA, Zhu Y, Plajzer-Frick I, Pickle CS, Kato M, Garvin TH, Pham QT, Harrington AN, Akiyama JA, Afzal V, Lopez-Rios J, Dickel DE, Visel A, Pennacchio LA. Osterwalder M, et al. Nature. 2018 Feb 8;554(7691):239-243. doi: 10.1038/nature25461. Epub 2018 Jan 31. Nature. 2018. PMID: 29420474 Free PMC article.