Group G Streptococcus Infective Endocarditis in Association With Colon Cancer

Abstract

Group G streptococcus has been increasingly reported as a cause of bacteremia and infective endocarditis. The association between various groups of streptococcus with malignancy has been well established. Such association is particularly observed in group D Streptococcus bovis which is commonly reported in association with carcinoma of the colon. We herein report a case of a 72-year-old male who presented with severe sepsis, iron deficiency anemia and newly diagnosed cardiac murmur. Further workup confirmed group G streptococcus bacteremia, infective endocarditis and newly diagnosed carcinoma of the colon. This case highlights a unique association between invasive form of group G streptococcus and colon cancer.

Keywords: Colon cancer; Group G streptococcus; Infective endocarditis.

Figure 1

TEE three-chamber view of the mid esophageal region showing 2 mm vegetation along the aortic valve.

Figure 2

(a) Endoscopic view showing sigmoid colon mass. (b) Microscopic view of biopsy of the sigmoid colon lesion at × 100 magnification showing adenocarcinoma next to benign colonic glands for comparison. (c) Microscopic view of biopsy of sigmoid colon at × 200 magnification showing nuclear and architectural pleomorphism and mitoses.

Figure 3

(a) Endoscopic view showing partially obstructing mass in the transverse colon. (b) Biopsy of the transverse colon mass at × 200 magnification showing adenocarcinoma.