Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017:2017:2793205.
doi: 10.1155/2017/2793205. Epub 2017 Nov 28.

Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?

Clebson Pantoja Pimentel  1 , Erik Artur Cortinhas-Alves  1   2 , Edivaldo Herculano Correa de Oliveira  3   4 , Luiz Carlos Santana-da-Silva  1
Affiliations

Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?

Clebson Pantoja Pimentel et al. J Thyroid Res. 2017.

Abstract

Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing. Results. More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16. Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis. There was no difference between agenesis group and control group. Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis. Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flowchart diagram of this study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Van Vliet G., Deladoëy J. Diagnosis, treatment and outcome of congenital hypothyroidism. Endocrine Development. 2014;26:50–59. doi: 10.1159/000363155. - DOI - PubMed
    1. Wassner A. J., Brown R. S. Congenital hypothyroidism: Recent advances. Current Opinion in Endocrinology, Diabetes and Obesity. 2015;22(5):407–412. doi: 10.1097/MED.0000000000000181. - DOI - PubMed
    1. Abu-Khudir R., Larrivée-Vanier S., Wasserman J. D., Deladoëy J. Disorders of thyroid morphogenesis. Best Practice & Research: Clinical Endocrinology. 2017;31(2):143–159. - PubMed
    1. Nilsson M., Fagman H. Development of the thyroid gland. Development. 2017;144(12):2123–2140. - PubMed
    1. Clifton-Bligh R. J., Wentworth J. M., Heinz P., et al. Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia. Nature Genetics. 1998;19(4):399–401. doi: 10.1038/1294. - DOI - PubMed

LinkOut - more resources