Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb 26;19(2):351-355.
doi: 10.22034/APJCP.2018.19.2.351.

Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer

Xin Zhang  1 , Ye Niu, Xin Wang, Zhi-ping Liu, Tiemin Liu, Rui- Tao Wang
Affiliations

Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer

Xin Zhang et al. Asian Pac J Cancer Prev. .

Abstract

Gallbladder cancer (GBC) represents the most common biliary tract malignancy. Activated platelets play an essential role in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used indexes of activated platelets in clinical practice. The aim of the current study was to investigate the association of MPV and PDW with GBC. 104 GBC patients and 109 normal control subjects were entered in this study between January 2015 and December 2015. We collected all participants’ clinical and laboratory characteristics at initial diagnosis. The odds ratios (ORs) for GBC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV and PDW quartiles. MPV levels were markedly lower and PDW levels were remarkably higher in GBC patients than control subjects. A significant correlation between PDW and lymph node metastasis was detected. In addition, after adjusting for other risk factors, the ORs (95% CIs) for GBC in each MPV quartile were 5.117 (1.939-13.506), 2.444 (0.917-6.516), 3.718 (1.381-10.007), and 1.000, respectively. The ORs (95% CIs) for GBC in each PDW quartile were 1.000, 2.063 (0.825-5.162), 3.070 (1.108-8.507), and 12.108 (4.243-34.553), respectively. In conclusion, decreased MPV and elevated PDW were independently associated with GBC. Our findings suggest that MPV and PDW are available parameters for early detection of GBC.

Keywords: Gallbladder cancer; mean platelet volume; platelet distribution width; diagnosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Prevalence Rate of Gallbladder Cancer in the Subjects with Different Quartiles of Mean Platelet Volume.
Figure 2
Figure 2
Prevalence Rate of Gallbladder Cancer in The Subjects with Different Quartiles of Platelet Distribution Width.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Al-Mondhiry H. beta-Thromboglobulin and platelet-factor 4 in patients with cancer:correlation with the stage of disease and the effect of chemotherapy. Am J Hematol. 1983;14:105–11. - PubMed
    1. Ay C, Simanek R, Vormittag R, et al. High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients:results from the Viennacancer and thrombosis study (CATS) Blood. 2008;112:2703–8. - PubMed
    1. Bambace NM, Holmes CE. The platelet contribution to cancer progression. J Thromb Haemost. 2011;9:237–49. - PubMed
    1. Brown AS, Hong Y, de Belder A, et al. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol. 1997;17:802–7. - PubMed
    1. Chadha AS, Kocak-Uzel E, Das P, et al. Paraneoplastic thrombocytosis independently predicts poor prognosis in patients with locally advanced pancreatic cancer. Acta Oncol. 2015;54:971–8. - PubMed