Methodical aspects of the experimental chemotherapy of viral infections
- PMID: 29480
Methodical aspects of the experimental chemotherapy of viral infections
Abstract
An analysis of the methods of testing the antiviral activity in vitro (in cell cultures) and in vivo (in experimental virus infections) is presented. The necessity of applying two-stage screening in vitro is emphasized. The chemotherapeutic viral models is in vitro testing as well as the principles of modelling of experimental viral infections are examined. Criteria for stage-by-stage assessment of the antiviral activity of the substances tested are formulated.
Similar articles
-
Three-dimensional culture models for human viral diseases and antiviral drug development.Antiviral Res. 2006 Sep;71(2-3):96-107. doi: 10.1016/j.antiviral.2006.05.023. Epub 2006 Jun 27. Antiviral Res. 2006. PMID: 16844237 Review.
-
[Antiviral chemotherapy in pediatrics--its present and prospects].Pediatrie (Bucur). 1992 Jan-Mar;41(1):46-52. Pediatrie (Bucur). 1992. PMID: 1322725 Review. Romanian.
-
The continuing search for antiviral drugs.Adv Pharmacol Chemother. 1973;11:295-318. Adv Pharmacol Chemother. 1973. PMID: 4585168 Review. No abstract available.
-
Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections.Expert Opin Drug Discov. 2012 Jul;7(7):597-611. doi: 10.1517/17460441.2012.689281. Epub 2012 May 19. Expert Opin Drug Discov. 2012. PMID: 22607384
-
Phosprenyl: a novel drug with antiviral and immunomodulatory activity.Arch Immunol Ther Exp (Warsz). 1996;44(5-6):395-400. Arch Immunol Ther Exp (Warsz). 1996. PMID: 9017158 Review.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources