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Review
. 2018;7(1):89-98.
doi: 10.3233/JHD-189001.

Huntington’s Disease Clinical Trials Corner: February 2018

Filipe B Rodrigues  1   2   3 , Edward J Wild  2
Affiliations
Review

Huntington’s Disease Clinical Trials Corner: February 2018

Filipe B Rodrigues et al. J Huntingtons Dis. 2018.

Abstract

In the second edition of the Huntington’s Disease Clinical Trials Corner we list all currently registered and ongoing clinical trials, summarise the top-line results of the recently-announced IONIS-HTTRX trial (NCT02519036), expand on Wave Life Sciences’ PRECISION-HD1 (NCT03225833) and PRECISION-HD2 (NCT03225846), and cover one recently finished trial: the FIRST-HD deutetrabenazine trial (NCT01795859).

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References

    1. Ionis Pharmaceuticals I. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-HTTRx in PatientsWith Early Manifest Huntington’s Disease. https://ClinicalTrials.gov/show/NCT02519036; 2015.
    1. Wave Life Sciences. Safety and Tolerability of WVE-120101 in Patients With Huntington’s Disease. https://ClinicalTrials.gov/show/NCT03225833; 2017.
    1. Wave Life Sciences. Safety and Tolerability of WVE-120102 in Patients With Huntington’s Disease. https://ClinicalTrials.gov/show/NCT03225846; 2017.
    1. Teva Pharmaceutical Industries. First Time Use of SD-809 in Huntington Disease. https://ClinicalTrials.gov/show/NCT01795859; 2013.
    1. Huntington Study Group. Effect of deutetrabenazine on chorea among patients with huntington disease: A randomized clinical trial. Jama. 2016;316(1):40–50. - PubMed

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