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Meta-Analysis
. 2018 Jan;97(2):e9438.
doi: 10.1097/MD.0000000000009438.

Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis

Hongquan Wan  1 , Chunguo Zhang, He Li, Shuxin Luan, Chang Liu
Affiliations
Meta-Analysis

Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis

Hongquan Wan et al. Medicine (Baltimore). 2018 Jan.

Abstract

Studies on the association of maternal diabetes with autism spectrum disorders (ASDs) in offspring provide inconsistent findings; therefore an updated and comprehensive literature review and meta-analysis is necessary to perform in order to evaluate the available evidences.After searching databases systematically, we established the inclusion criteria and selected the eligible studies. In both overall and stratified analyses, the estimated effects were synthesized dependent on the presence or absence of heterogeneity.Twelve articles involving 16 studies were included and synthesized, demonstrating a significant association of maternal diabetes with ASDs among children (relative risk [RR] = 1.48). However, high heterogeneity was observed (I = 56.3%) and publication bias was identified. In terms of the analyses on reliable evidences from case-control studies, heterogeneity and publication bias disappeared, and the risk of ASDs was increased by 62% among diabetic mothers compared with non-diabetic mothers.Maternal diabetes, especially gestational diabetes mellitus, is associated with ASDs in offspring based on a limited number of convincing case-control studies. More large-scale population-based prospective studies are still needed to draw firm conclusions.

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Conflict of interest statement

The authors have no conflicts of interest to declare regarding this article.

Figures

Figure 1
Figure 1
Flow diagram of the process of study selection.
Figure 2
Figure 2
Meta-analysis of all included studies. (A) Forest plot of the meta-analysis; (B) funnel plot of the meta-analysis; (C) sensitivity analysis.
Figure 3
Figure 3
Meta-analysis of moderate and high quality case-control studies. (A) Forest plot of the meta-analysis; (B) funnel plot of the meta-analysis; (C) sensitivity analysis.
See this image and copyright information in PMC

References

    1. Xiang AH, Wang X, Martinez MP, et al. Association of maternal diabetes with autism in offspring. JAMA 2015;313:1425–34. - PubMed
    1. Precenzano F, Ruberto M, Parisi L, et al. Executive functioning in preschool children affected by autism spectrum disorder: a pilot study. Acta Medica Mediterranea 2017;33:35.
    1. Parisi L, Fortunato MR, Salerno M, et al. Sensory perception in preschool children affected by autism spectrum disorders: a pilot study. Acta Medica Mediterranea 2017;33:49.
    1. Precenzano F, Ruberto M, Parisi L, et al. Sleep habits in children affected by autism spectrum diorders: a preliminary case-control study. Acta Medica Mediterranea 2017;33:405.
    1. Parisi L, Salerno M, Maltese A, et al. Autonomic regulation in autism spectrum disorders. Acta Medica Mediterranea 2017;33:491.