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Review
. 2018 Feb 26;9(1):44.
doi: 10.1186/s13287-018-0773-9.

Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications

Xiaofei Guo  1 , Yan Bai  1 , Li Zhang  1 , Bo Zhang  1 , Naufal Zagidullin  2 , Katherine Carvalho  3 , Zhimin Du  1 , Benzhi Cai  4
Affiliations
Review

Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications

Xiaofei Guo et al. Stem Cell Res Ther. .

Abstract

In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapeutic strategy because of its capacity to differentiate into cardiac cells. Current research indicates that chemical substances, microRNAs, and cytokines have biological functions that regulate the cardiomyocytes differentiation of BMSCs. In this review, we chiefly summarize the regulatory factors that induce BMSCs to differentiate into cardiomyocytes.

Keywords: Bone marrow-derived mesenchymal stem cells; Cardiomyocytes; Cytokines; Differentiation; Microenvironment; microRNAs.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
The regulators which can differentiate BMSCs into cardiomyocytes. BMSC bone marrow-derived mesenchymal stem cell, HDAC histone deacetylase, TGF-β transforming growth factor beta, VR-1 vanilloid receptor 1, 5-aza 5-azacytidine
See this image and copyright information in PMC

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