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Comment
. 2018 Apr;24(4):335-337.
doi: 10.1016/j.molmed.2018.02.005. Epub 2018 Feb 23.

Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3

Luke A J O'Neill  1 , Zbigniew Zaslona  2
Affiliations
Comment

Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3

Luke A J O'Neill et al. Trends Mol Med. 2018 Apr.

Abstract

In a recent study, Christ and colleagues identify a key role for NLRP3/IL-1beta in the induction of innate immune memory in monocytes by the Western diet, promoting atherosclerosis and inflammatory diseases.

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Comment on

  • Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
    Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E. Christ A, et al. Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013. Cell. 2018. PMID: 29328911 Free PMC article.

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