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Case Reports
. 2017 Dec 31;6(1):61-63.
doi: 10.3889/oamjms.2018.020. eCollection 2018 Jan 25.

Simultaneous Occurrence of Balanoposthitis Circumscripta Plasmacellularis Zoon, Phimosis and in Situ Carcinoma of the Penis: Case Report with An Unusual Ulcerated Polypoid Variant of Zoon's Disease and a Carcinoma in Situ of Reserve Cell Type

Uwe Wollina  1 , Jacqueline Schönlebe  2 , Alberto Goldman  3 , Georgi Tchernev  4   5 , Torello Lotti  6
Affiliations
Case Reports

Simultaneous Occurrence of Balanoposthitis Circumscripta Plasmacellularis Zoon, Phimosis and in Situ Carcinoma of the Penis: Case Report with An Unusual Ulcerated Polypoid Variant of Zoon's Disease and a Carcinoma in Situ of Reserve Cell Type

Uwe Wollina et al. Open Access Maced J Med Sci. .

Abstract

Background: Zoon's balanitis is a benign disease characterized by an asymptomatic, chronic, solitary, shiny, red-orange plaque of the glans and/ or prepuce. In rare cases of Zoon's disease, penile squamous cell carcinoma developed in the chronic inflammatory lesions.

Case report: We report on a 68-year-old male patient presenting with phimosis and coexistent Zoon's disease and penile carcinoma in situ treated successfully by circumcision.

Conclusion: Coexistence of both lesions in contrast to the development of cancerous lesions within pre-existent Zoon's disease is a very rare observation.

Keywords: Balanitis plasmacellularis Zoon; Carcinoma in situ; Circumcision; HPV; Morbus Queyrat; Penile cancer; Pimosis.

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Figures

Figure 1
Figure 1
Strawberry-like reddish papules of the penis – clinical presentation of carcinoma in situ
Figure 2
Figure 2
(a) Circumcision of the penis to remove the in situ carcinoma and to correct phimosis; (b) Surgical specimen; (c) Erosive Zoon’s disease; (d) After suturing
Figure 3
Figure 3
Histopathology. (a) Carcinoma in situ with plump epithelial taps (hematoxylinin-eosin x 10). (b) Collagen IV immmunoperoxidase staining showing an intact basal cell membrane (x 4). Erosive Zoon’s disease with lichenoid dermal inflammatory infiltrate (c; x 4), composed of plasma cells and lymphocytes (d; x 20)
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