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Case Reports
. 2018 Jan 7;6(1):76-78.
doi: 10.3889/oamjms.2018.039. eCollection 2018 Jan 25.

A "Yellow Submarine" in Dermoscopy

Francesca Satolli  1 , Miriam Rovesti  1 , Alfredo Zucchi  1 , Marco Gandolfi  1 , Claudio Feliciani  1 , Georgi Tchernev  2   3 , Uwe Wollina  4 , Serena Gianfaldoni  5 , Torello Lotti  6
Affiliations
Case Reports

A "Yellow Submarine" in Dermoscopy

Francesca Satolli et al. Open Access Maced J Med Sci. .

Abstract

Background: Histiocytic sarcoma (HS) is an extremely rare, non-Langerhans cell tumor. HS affects especially adults, its etiology is unknown yet. Skin could be interested by papules or nodules, single or multiple.

Case report: A Caucasian man in his late 40s came to our clinic for a naevi evaluation. During the visit, a rose papulonodular lesion was observed in the lumbar region. This lesion was completely asymptomatic, and it had been there for an indefinite period. The clinical evaluation revealed that the lesion appeared elevated, of 9 x 15 mm in dimension, symmetrical and of a homogeneous pinkish colour. The videodermoscopical evaluation revealed a homogeneous yellow central pattern, polymorphic vessels, an eccentric peripheral pigmentation and a white collar. An excisional biopsy was performed. The morphology and the expression of CD163, CD68 and/or lysozyme to the immunophenotypic analysis, revealed the true nature of the lesion.

Conclusion: HS is usually diagnosed at an already advanced clinical stage and it has a high mortality rate even today. Dermoscopy, showing a yellow and distributed homogeneously colour, can facilitate its hard diagnosis.

Keywords: CD68; WHO classification lymphomas; dermoscopy; histiocytic sarcoma; yellow colour.

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Figures

Figure 1
Figure 1
Clinical evaluation (A, B)
Figure 2
Figure 2
Dermoscopic evaluation
Figure 3
Figure 3
Morphology
Figure 4
Figure 4
Immunophenotype (first line, from left to right: CD4, CD68; second line, from left to right: CD163, Ki67). [Courtesy of Dr Mancini C., Unità Operativa di Anatomia e Istologia Patologica, Dipartimento Diagnostico, Università degli Studi di Parma]
See this image and copyright information in PMC

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