Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jan 13;6(1):120-122.
doi: 10.3889/oamjms.2018.010. eCollection 2018 Jan 25.

A Patient with Multiple Keratinocytic Cancers (MKC): Uncommon Presentation in a Bulgarian Patient

Georgi Tchernev  1   2 , Stanislav Philipov  3 , Anastasiya Atanasova Chokoeva  4 , Uwe Wollina  5 , Torello Lotti  6 , Ilia Lozev  7 , Irina Yungareva  1 , Georgi Konstantinov Maximov  2
Affiliations
Case Reports

A Patient with Multiple Keratinocytic Cancers (MKC): Uncommon Presentation in a Bulgarian Patient

Georgi Tchernev et al. Open Access Maced J Med Sci. .

Abstract

Keratinocyte skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancer occurring in people with fair skin, worldwide. Despite all known triggers, several suggested contributors are still investigated. We will focus our attention on the personal history of previous cancers and radiation exposure as occupational risk factors, as in the presented case. We report a patient, with multiple BCCs, and subsequent occurrence of a SCC on photo-exposed area of the face, as we want to emphasize the importance of strict following up of these patients, regarding the risk for developing new tumors in short periods of time, no matter if the triggering exposure factor is known from the history, or not. Although keratinocytes tumours are associated with the low mortality rate, we focus the attention on the fact, that the history of non-melanoma skin cancer is associated with increased mortality.

Keywords: basal cell carcinoma; island flap; skin cancer; squamous cell carcinoma; surgery.

PubMed Disclaimer

Figures

Figure 1
Figure 1
a - Clinical manifestation of a tumour, prior the surgical excision; b, c, d, e - Intraoperative finding. Oval shaped excision of a tumour with the preparation of the island flap; f - Postoperative findings. The surgical wound is closed with single stitches
Figure 2
Figure 2
Histopathological findings, confirming the diagnosis of SCC (H&Ex100): a - Aggregates of atypical epithelial cells invading the dermis. The nonspecific inflammatory infiltrates with lymphocytes and plasma cells; b - Lobules and nests of atypical, acantholytic keratinocytes. Premature cornification with free-floating neoplastic keratinocytes. Cellular aggregates with vascular appearance; c, d - Aggregates of atypical epithelial cells invading the dermis. The nonspecific inflammatory infiltrates with lymphocytes and plasma cells. Erythrocytes contained in pseudovascular spaces. Moderate mitotic activity. Premature cornification
See this image and copyright information in PMC

References

    1. Perera E, Gnaneswaran N, Staines C, Win AK, Sinclair R. Incidence and prevalence of non-melanoma skin cancer in Australia:A systematic review. Australas J Dermatol. 2015;56(4):258–67. https://doi.org/10.1111/ajd.12282 PMid:25716064. - PubMed
    1. Xiang F, Lucas R, Hales S, Neale R. Incidence of nonmelanoma skin cancer about ambient UV radiation in white populations 1978-2012:empirical relationships. JAMA Dermatol. 2014;150(10):1063–71. https://doi.org/10.1001/jamadermatol.2014.762 PMid:25103031. - PubMed
    1. Skin cancer (non-melanoma) - risks factors and prevention. American Society of Clinical Oncology (ASCO) Cancer.Net. Alexandria, VA: American Society of Clinical Oncology (ASCO); 2013. Dec, http://www.cancer.ca/en/cancer-information/cancer-type/skin-non-melanoma... .
    1. Burgdorf W, Plewig G, Wolf H, Landtheler M, et al. Braun Falco's Dermatology. Other syndromes associated with increased risk for Basal cell carcinoma. 3rd edition. Chapter 95. Springer; 2009. p. 355. https://doi.org/10.1007/978-3-540-29316-3.
    1. Yanik EL, Pfeiffer RM, Freedman DM, Weinstock MA, Cahoon EK, Arron ST, Chaloux M, Connolly MK, Nagarajan P, Engels EA. The spectrum of Immune-Related Conditions Associated with Risk of Keratinocyte Cancers among Elderly Adults in the United States. Cancer Epidemiol Biomarkers Prev. 2017;26(7):998–1007. https://doi.org/10.1158/1055-9965.EPI-17-0003 PMid:28377416. - PMC - PubMed

Publication types

LinkOut - more resources