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Case Reports
. 2018 Jan 13;6(1):120-122.
doi: 10.3889/oamjms.2018.010. eCollection 2018 Jan 25.

A Patient with Multiple Keratinocytic Cancers (MKC): Uncommon Presentation in a Bulgarian Patient

Georgi Tchernev  1   2 , Stanislav Philipov  3 , Anastasiya Atanasova Chokoeva  4 , Uwe Wollina  5 , Torello Lotti  6 , Ilia Lozev  7 , Irina Yungareva  1 , Georgi Konstantinov Maximov  2
Affiliations
Case Reports

A Patient with Multiple Keratinocytic Cancers (MKC): Uncommon Presentation in a Bulgarian Patient

Georgi Tchernev et al. Open Access Maced J Med Sci. .

Abstract

Keratinocyte skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancer occurring in people with fair skin, worldwide. Despite all known triggers, several suggested contributors are still investigated. We will focus our attention on the personal history of previous cancers and radiation exposure as occupational risk factors, as in the presented case. We report a patient, with multiple BCCs, and subsequent occurrence of a SCC on photo-exposed area of the face, as we want to emphasize the importance of strict following up of these patients, regarding the risk for developing new tumors in short periods of time, no matter if the triggering exposure factor is known from the history, or not. Although keratinocytes tumours are associated with the low mortality rate, we focus the attention on the fact, that the history of non-melanoma skin cancer is associated with increased mortality.

Keywords: basal cell carcinoma; island flap; skin cancer; squamous cell carcinoma; surgery.

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Figures

Figure 1
Figure 1
a - Clinical manifestation of a tumour, prior the surgical excision; b, c, d, e - Intraoperative finding. Oval shaped excision of a tumour with the preparation of the island flap; f - Postoperative findings. The surgical wound is closed with single stitches
Figure 2
Figure 2
Histopathological findings, confirming the diagnosis of SCC (H&Ex100): a - Aggregates of atypical epithelial cells invading the dermis. The nonspecific inflammatory infiltrates with lymphocytes and plasma cells; b - Lobules and nests of atypical, acantholytic keratinocytes. Premature cornification with free-floating neoplastic keratinocytes. Cellular aggregates with vascular appearance; c, d - Aggregates of atypical epithelial cells invading the dermis. The nonspecific inflammatory infiltrates with lymphocytes and plasma cells. Erythrocytes contained in pseudovascular spaces. Moderate mitotic activity. Premature cornification
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