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. 2018 Jan;44(1):31-35.
doi: 10.5152/tud.2018.91455. Epub 2018 Jan 8.

Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma

Farahnaz Norouzinia  1 , Fariba Abbasi  1 , Sina Dindarian  2 , Sedra Mohammadi  2 , Farid Meisami  1 , Mahdi Bagheri  2 , Hozan Mohammadi  3
Affiliations

Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma

Farahnaz Norouzinia et al. Turk J Urol. 2018 Jan.

Abstract

Objective: Renal cell carcinomas (RCCs) include about 2% of adult neoplasms and 90-95% of all renal tumors. Mostly, it is possible to distinguish RCC subtypes using hematoxylin-eosin staining. However, overlapping morphologic features cause some difficulties in making a precise diagnosis. In order to render an accurate diagnosis, additional methods such as immunohistochemical staining for c-kit have been recommended. In this study, we aimed to investigate c-kit gene expression in various subtypes of RCC.

Material and methods: We reviewed 65 diagnosed RCC cases. Formalin- fixed, paraffin- embedded specimens were available for the cases. The expression of c-kit was evaluated using immunohistochemistry. The correlation between c-kit expression and clinicopathological parameters including patients' age and gender in addition to grade, stage, and size of the tumor were investigated.

Results: Six cases of 39 clear cell types (15.4%), 8 of 13 papillary types (61.5%), 11 of 12 chromophobe types (91.7%), and no sarcomatoid type were positive for c-kit expression. Based on chi-square test results, there was a significant relationship between RCC subtypes and c-kit expression (p=0.001). There was no significant correlation between age, sex, grade, stage, and size of the tumor and c-kit expression.

Conclusion: The expression of c-kit in RCC may have diagnostic significance in subtypes of RCC especially papillary and chromophobe subtypes of RCC.

Keywords: C-kit; H&E staining; KIT; renal cell carcinoma.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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