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Review
. 2018 Sep;104(3):484-494.
doi: 10.1002/cpt.1034. Epub 2018 Feb 27.

Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development

Musaddique Hussain  1   2 , Chengyun Xu  1   2 , Mashaal Ahmad  1   2 , Abdul Majeed  3 , Meiping Lu  4 , Xiling Wu  4 , Lanfang Tang  4 , Ximei Wu  1   2
Affiliations
Review

Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development

Musaddique Hussain et al. Clin Pharmacol Ther. 2018 Sep.

Abstract

Despite 50 years of extensive research, no definite drug is currently available to treat acute respiratory distress syndrome (ARDS), and the supportive therapies remain the mainstay of treatment. To improve drug development for ARDS, researchers need to deeply analyze the "omics" approaches, reevaluate the suitable therapeutic targets, resolve the problems of inadequate animal modeling, develop the strategies to reduce the heterogeneity, and reconsider new therapeutic and analytical approaches for better designs of clinical trials.

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Conflict of interest statement

The authors declare no competing interests for this work.

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