Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Aug;51(4):e12446.
doi: 10.1111/cpr.12446. Epub 2018 Feb 27.

The long non-coding RNA SPRY4-IT1: An emerging player in tumorigenesis and osteosarcoma

Zheng Li  1 , Jianxiong Shen  1 , Matthew T V Chan  2 , William Ka Kei Wu  2   3
Affiliations
Review

The long non-coding RNA SPRY4-IT1: An emerging player in tumorigenesis and osteosarcoma

Zheng Li et al. Cell Prolif. 2018 Aug.

Abstract

Accumulating evidence from genome-wide analysis and functional studies has begun to unveil the important role of long non-coding RNAs (lncRNAs) in cancer development. The lncRNA SPRY4-IT1 is derived from an intron of SPRY4 gene and was originally reported to be upregulated in melanoma in which it functioned as an oncogene. Since this discovery, an increasing number of studies have investigated the expression and function of SPRY4-IT1 in human cancers. Aberrant expression of SPRY4-IT1 has now been documented in different cancer types, including osteosarcoma, breast, renal, oesophageal and prostate cancers. However, its deregulation and function in lung and gastric cancers remain controversial. Pertinent to clinical practice, SPRY4-IT1 expression has been shown to predict survival of cancer patients. In this review, we summarize recent evidence concerning SPRY4-IT1 deregulation and the associated mechanisms in human cancers. We also discuss the potential clinical utilization of this lncRNA as a diagnostic and prognostic biomarker for cancer patients.

Keywords: SPRY4-IT1; cancer; lncRNA; osteosarcoma; prognosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Upstream regulatory and downstream molecular mechanisms underlying SPRY4‐IT1 upregulation in human cancers
See this image and copyright information in PMC

References

    1. Yoshimoto R, Mayeda A, Yoshida M, Nakagawa S. MALAT1 long non‐coding RNA in cancer. Biochim Biophys Acta. 2015;1859:192‐199. - PubMed
    1. Tano K, Akimitsu N. Long non‐coding RNAs in cancer progression. Front Genet. 2012;3:219. - PMC - PubMed
    1. Zhang J, Zhang P, Wang L, Piao HL, Ma L. Long non‐coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochim Biophys Sin (Shanghai). 2014;46:1‐5. - PMC - PubMed
    1. Sorensen KP, Thomassen M, Tan Q, et al. Long non‐coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor‐positive primary breast cancer. Breast Cancer Res Treat. 2013;142:529‐536. - PubMed
    1. He X, Bao W, Li X, et al. The long non‐coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. Int J Mol Med. 2014;33:325‐332. - PubMed

MeSH terms

Substances

Associated data