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Review
. 2018 Sep;38(5):1614-1660.
doi: 10.1002/med.21492. Epub 2018 Feb 27.

Biologically active quinoline and quinazoline alkaloids part II

Xiao-Fei Shang  1   2 , Susan L Morris-Natschke  3 , Guan-Zhou Yang  2 , Ying-Qian Liu  2 , Xiao Guo  4 , Xiao-Shan Xu  2 , Masuo Goto  3 , Jun-Cai Li  2 , Ji-Yu Zhang  1 , Kuo-Hsiung Lee  3   5
Affiliations
Review

Biologically active quinoline and quinazoline alkaloids part II

Xiao-Fei Shang et al. Med Res Rev. 2018 Sep.

Abstract

To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

Keywords: biological activities; camptothecin; natural products; quinazoline alkaloids; quinoline alkaloids.

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Figures

Figure 1
Figure 1
Chemical structures of compounds 1–8
Figure 2
Figure 2
Chemical structures of compounds 9–11
Figure 3
Figure 3
Chemical structures of compounds 12–35
Figure 4
Figure 4
Chemical structures of compounds 36–40
Figure 5
Figure 5
Chemical structures of compounds 41–45
Figure 6
Figure 6
Chemical structures of compounds 46–49
Figure 7
Figure 7
Chemical structures of compounds 50–53
Figure 8
Figure 8
Chemical structures of compounds 54–63
Figure 9
Figure 9
Chemical structures of compounds 64–67
Figure 10
Figure 10
Chemical structures of compounds 68–74
Figure 11
Figure 11
Chemical structures of compounds 75–78
Figure 12
Figure 12
Chemical structures of compounds 79–86
Figure 13
Figure 13
Chemical structures of compounds 87–105
Figure 14
Figure 14
Chemical structures of compounds 106–109
Figure 15
Figure 15
Chemical structures of compounds 110–120
Figure 16
Figure 16
Chemical structures of compounds 121–132
Figure 17
Figure 17
Chemical structures of compounds 133–146
Figure 18
Figure 18
Chemical structures of compounds 147–150
Figure 19
Figure 19
Chemical structures of compounds 151–158
Figure 20
Figure 20
Chemical structures of compounds 165–171
Figure 21
Figure 21
Chemical structures of compounds 172–177
Figure 22
Figure 22
Chemical structures of compounds 178 and 179
Figure 23
Figure 23
Chemical structures of compounds 180–193
Figure 24
Figure 24
Chemical structures of compounds 194–197
Figure 25
Figure 25
Chemical structures of compounds 198
Figure 26
Figure 26
Chemical structures of compounds 199–202
Figure 27
Figure 27
Chemical structures of compounds 203–213
Figure 28
Figure 28
Chemical structures of compounds 214–217
Figure 29
Figure 29
Chemical structures of compounds 218–224
Figure 30
Figure 30
Chemical structures of compounds 225–229
Figure 31
Figure 31
Chemical structures of compounds 230–234
Figure 32
Figure 32
Chemical structures of compounds 235
Figure 33
Figure 33
Chemical structures of compounds 236–244
Figure 34
Figure 34
Chemical structures of compounds 245
Figure 35
Figure 35
Chemical structures of compounds 246
Figure 36
Figure 36
Chemical structures of compounds 247–252
Figure 37
Figure 37
Chemical structures of compounds 253–255
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References

    1. Prajapati SM, Patel KD, Vekariya RH, Panchal SN, Patel HD. Recent advances in the synthesis of quinolines: a review. RSC Adv. 2014;4:24463–24476.
    2. Asif M. Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives. Int J Med Chem. 2014;2014:395637. doi: 10.1155/2014/395637. - DOI - PMC - PubMed
    3. Rajput R, Mishra AP. A review on biological activity of quinazolinones. Int J Pharm Pharm Sci. 2012;4:66–70.
    1. Wiesner J, Ortmann R, Jomaa H, Schlitzer M. New antimalarial drugs. Angew Chem Int Ed. 2003;42:5274–5293. - PubMed
    1. Manske RH. The chemistry of quinolines. Chem Rev. 1942;30:113–144.
    1. Anjali PD, Singh D. Quinoline: a diverse therapeutic agent. Int J Pharm Sci Res. 2016;7:1–13.
    1. Afzal O, Kumar S, Haider MR, Ali MR, Kumar R, Jaggi M, Bawa S. A review on anticancer potential of bioactive heterocycle quinoline. Europ J Med Chem. 2015;97:871–910. - PubMed
    2. Selvan TP, Kumar PV. Quinazoline marketed drugs – a review. Res Pharmacy. 2011;1:1–21.
    3. Tiwary BK, Pradhan KP, Nanda AK, Chakraborty R. Implication of quinazoline-4(3H)-ones in medicinal chemistry: a brief review. J Chem Biol Ther. 2015;1 article 104.
    4. Patel DB, Vekariyz RH, Patel KD, Projapati NP, Vasava MS, Patel HD. Recent advances in synthesis of quinoline-4-carboxylic acid and their biological evaluation: a review. J Chem Pharm Res. 2017;9:216–230.

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