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Clinical Trial
. 2018 Jul 15;198(2):265-267.
doi: 10.1164/rccm.201801-0051LE.

Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials

MeiLan K Han  1 , Nabihah Tayob  2 , Susan Murray  1 , Prescott G Woodruff  3 , Jeffrey L Curtis  1   4 , Victor Kim  5 , Gerard Criner  5 , Craig J Galban  6 , Brian D Ross  6 , Eric A Hoffman  1 , David A Lynch  7 , Ella Kazerooni  6 , Fernando J Martinez  1   8 ; COPDGene and SPIROMICS Investigators
Affiliations
Clinical Trial

Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials

MeiLan K Han et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Plot of mean exacerbations per year by percentage emphysema in COPDGene (COPD Genetic Epidemiology; left) and SPIROMICS (Subpopulations and Intermediate Outcomes in COPD Study; right). Black dots represent raw averages for exacerbation rates grouped by nearest emphysema percentile. Age-adjusted estimates for average exacerbations per year shown via linear splines in black (using every percentile of emphysema) and smoothed splines in red. Mean follow-up time was 4.06 years.
Figure 2.
Figure 2.
Plot of average deaths per 100 person-years by percentage emphysema in COPDGene (COPD Genetic Epidemiology; left) and SPIROMICS (Subpopulations and Intermediate Outcomes in COPD Study; right). Black dots represent raw averages for death rates grouped by nearest emphysema percentile. Age-adjusted estimates for average deaths per 100 person-years are shown via linear splines in black (using every percentile of emphysema) and smoothed splines in red. The y-axis of each graph is truncated at 10 average deaths per 100 person-years to allow better visual comparison of both cohorts.
See this image and copyright information in PMC

References

    1. Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, et al. COPDGene Investigators. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax. 2012;67:399–406. - PMC - PubMed
    1. Grydeland TB, Dirksen A, Coxson HO, Eagan TM, Thorsen E, Pillai SG, et al. Quantitative computed tomography measures of emphysema and airway wall thickness are related to respiratory symptoms. Am J Respir Crit Care Med. 2010;181:353–359. - PubMed
    1. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, et al. COPDGene Investigators. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011;261:274–282. - PMC - PubMed
    1. Zulueta JJ, Wisnivesky JP, Henschke CI, Yip R, Farooqi AO, McCauley DI, et al. Emphysema scores predict death from COPD and lung cancer. Chest. 2012;141:1216–1223. - PMC - PubMed
    1. Oelsner EC, Hoffman EA, Folsom AR, Carr JJ, Enright PL, Kawut SM, et al. Association between emphysema-like lung on cardiac computed tomography and mortality in persons without airflow obstruction: a cohort study. Ann Intern Med. 2014;161:863–873. - PMC - PubMed

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