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Review
. 2018 Jul 1;315(1):E1-E6.
doi: 10.1152/ajpendo.00014.2018. Epub 2018 Feb 27.

Microbiota and metabolism: what's new in 2018?

Alexis Bretin  1 , Andrew T Gewirtz  1 , Benoit Chassaing  1   2
Affiliations
Review

Microbiota and metabolism: what's new in 2018?

Alexis Bretin et al. Am J Physiol Endocrinol Metab. .

Abstract

The concept that the gut microbiota plays a broadly important role in health and disease in general, and metabolic health in particular, is now well established. However, many of the underlying mechanisms remain poorly understood while approaches to reliably manipulate the microbiota to promote health have not yet been clearly defined. Nonetheless, progress in these areas is steadily accelerating. Herein, we review select areas of progress that have been made in the last year that should hasten the era in which the microbiota can be therapeutically manipulated to promote metabolic health.

Keywords: inflammation; metabolic disorders.

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Figures

Fig. 1.
Fig. 1.
Overview of the recent findings regarding diet impacts on the microbiota with consequences on host metabolism. AHR, aryl hydrocarbon receptor; SCFA, short-chain fatty acid; IL-22, interleukin-22.
See this image and copyright information in PMC

References

    1. Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 147: 1055–1063, 2014. doi:10.1053/j.gastro.2014.07.020. - DOI - PMC - PubMed
    1. Anhê FF, Nachbar RT, Varin TV, Vilela V, Dudonné S, Pilon G, Fournier M, Lecours MA, Desjardins Y, Roy D, Levy E, Marette A. A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss. Mol Metab 6: 1563–1573, 2017. doi:10.1016/j.molmet.2017.10.003. - DOI - PMC - PubMed
    1. Anhê FF, Roy D, Pilon G, Dudonné S, Matamoros S, Varin TV, Garofalo C, Moine Q, Desjardins Y, Levy E, Marette A. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64: 872–883, 2015. doi:10.1136/gutjnl-2014-307142. - DOI - PubMed
    1. Anhê FF, Varin TV, Le Barz M, Desjardins Y, Levy E, Roy D, Marette A. Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts. Curr Obes Rep 4: 389–400, 2015. doi:10.1007/s13679-015-0172-9. - DOI - PubMed
    1. Burrough ER, Arruda BL, Plummer PJ. Comparison of the Luminal and Mucosa-Associated Microbiota in the Colon of Pigs with and without Swine Dysentery. Front Vet Sci 4: 139, 2017. doi:10.3389/fvets.2017.00139. - DOI - PMC - PubMed

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