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Comment
. 2018 Feb 26;44(4):403-404.
doi: 10.1016/j.devcel.2018.02.004.

A Role for Ploidy in Heart Regeneration

Zachary A Kadow  1 , James F Martin  2
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Comment

A Role for Ploidy in Heart Regeneration

Zachary A Kadow et al. Dev Cell. .
Free article

Abstract

There is mounting circumstantial evidence that ploidy, a cell's relative DNA content, is in part responsible for the differential cardiac regenerative capacity observed between regenerative and non-regenerative organisms. In this issue of Developmental Cell, González-Rosa et al. (2018) provide direct evidence that polyploid cardiomyocytes have reduced proliferative and regenerative potential.

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