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. 2018 Mar;11(1):1-8.
doi: 10.21053/ceo.2017.00717. Epub 2018 Feb 22.

Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis

Bo Hae Kim  1 , Sung Joon Park  2 , Woo-Jin Jeong  3 , Soon-Hyun Ahn  2
Affiliations

Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis

Bo Hae Kim et al. Clin Exp Otorhinolaryngol. 2018 Mar.

Abstract

Objectives: This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses.

Methods: Twenty-five retrospective case-series studies were included in these analyses. Treatment strategies were classified as total laryngectomy (TL), open partial laryngectomy (PL), transoral laser microsurgery (TLM), chemo-radiation therapy (CRT), and radiation therapy (RT) alone.

Results: The overall survival rate and disease-specific survival rate among laryngeal preservation treatments did not differ from the overall survival rate of TL. However, the local control rate was lower with RT than TL and PL, and laryngeal preservation rates of TLM and CRT were higher than RT alone.

Conclusion: Consideration of preservation of laryngeal function is necessary when treating T3 glottic squamous cell carcinoma. PL, TLM, and, CRT are considered more appropriate initial laryngeal preservation strategies if available.

Keywords: Glottis; Meta-Analysis; Organ Preservation; Squamous Cell Carcinoma; Survival.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Flow chart of studies through the review.
Fig. 2.
Fig. 2.
A proportional meta-analysis of case series studies comparing overall survival rate after primary treatments in patients with T3 glottic squamous cell carcinoma.
Fig. 3.
Fig. 3.
A proportional meta-analysis of case series studies comparing disease-specific survival rate after primary treatments in patients with T3 glottic squamous cell carcinoma.
Fig. 4.
Fig. 4.
A proportional meta-analysis of case series studies comparing local control rate after primary treatments in patients with T3 glottic squamous cell carcinoma.
Fig. 5.
Fig. 5.
A proportional meta-analysis of case series studies comparing laryngeal preservation rate after primary treatments in patients with T3 glottic squamous cell carcinoma.
See this image and copyright information in PMC

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