Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar;31(2):121-126.
doi: 10.1055/s-0037-1609027. Epub 2018 Feb 25.

Meconium Ileus

Affiliations
Review

Meconium Ileus

John H T Waldhausen et al. Clin Colon Rectal Surg. 2018 Mar.

Abstract

Cystic fibrosis is one of the most common inheritable traits in Caucasians. Meconium ileus and its potential complications are the most likely reasons that these patients will need surgical care. Surgical intervention is usually needed in the neonatal period but may also be required later in life. This article discusses the various ways cystic fibrosis can affect the gastrointestinal tract. Both the operative and nonoperative management of complicated and uncomplicated meconium ileus are discussed in the neonatal period as well as long-term issues, such as distal intestinal obstructive syndrome, fibrosing colonopathy, and rectal prolapse, all of which may be seen in older children and adults.

Keywords: cystic fibrosis; cystic fibrosis transmembrane conductance regulator; distal intestinal obstruction syndrome; epithelial sodium channels; fibrosing colonopathy; meconium ileus; newborn intestinal obstruction; rectal prolapse.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Meconium ileus. Newborn with dilated loops of small bowel and a “doughy” abdomen.
Fig. 2
Fig. 2
Lack of air–fluid levels.
Fig. 3
Fig. 3
Abdominal X-ray (AXR) ground glass.
Fig. 4
Fig. 4
Types of ostomies for meconium ileus.

References

    1. Wilcken B, Wiley V, Sherry G, Bayliss U. Neonatal screening for cystic fibrosis: a comparison of two strategies for case detection in 1.2 million babies. J Pediatr. 1995;127(06):965–970. - PubMed
    1. Kleven D T, McCudden C R, Willis M S.Cystic fibrosis: newborn screening in America MLO Med Lab Obs 2008400716–18., 22, 24–27 - PubMed
    1. Kopp B T, Nicholson L, Paul G, Tobias J, Ramanathan C, Hayes D., Jr Geographic variations in cystic fibrosis: an analysis of the U.S. CF Foundation Registry. Pediatr Pulmonol. 2015;50(08):754–762. - PubMed
    1. Feuchtbaum L, Carter J, Dowray S, Currier R J, Lorey F. Birth prevalence of disorders detectable through newborn screening by race/ethnicity. Genet Med. 2012;14(11):937–945. - PubMed
    1. Sykes J, Stanojevic S, Goss C H et al. A standardized approach to estimating survival statistics for population-based cystic fibrosis registry cohorts. J Clin Epidemiol. 2016;70:206–213. - PMC - PubMed