Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Abstract

Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = -0.22, p = 0.019 for subjects with high hemoglobin, and β = -0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

Keywords: CD34-positive cell; CIMT; Gerotarget; height; platelets; vascular remodeling.

Figure 1. Scatter plot of platelets and height, and platelets and circulating CD34-positive cells

Figure 2. Possible mechanism underlying the association between height and vascular remodeling (endothelial repair)

The mechanism below the dotted line is observed only for subjects without severe age-related bone marrow activity reduction (subjects with high Hb). Relations in red were observed in the present analysis. Hb: hemoglobin. CIMT: carotid intima-media thickness.