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. 2017 Dec 21;9(8):8100-8110.
doi: 10.18632/oncotarget.23568. eCollection 2018 Jan 30.

Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China

Rui-Hua Liu #  1 , Ming-Ying Wang #  1   2 , Ling-Yun Chen #  3   2 , Zhi-Jie Yin  1 , Qian-Kun Ji  1 , Yang-Yang Wang  1 , Bao-Zhe Jin  1
Affiliations

Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China

Rui-Hua Liu et al. Oncotarget. .

Abstract

LncRNA actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) is often dysregulated in cancer. We performed this meta-analysis to clarify the usefulness of AFAP1-AS1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Augest 7, 2017. Sixteen studies with a total of 1,386 patients were included in the study. The pooled hazard ratio (HR) suggested high AFAP1-AS1 expression correlated with poor overall survival (OS) (HR = 1.98, 95% confidence interval (CI): 1.71-2.28), disease-free survival (DFS) (HR = 1.54, 95% CI: 1.22-1.95), and progression-free survival (PFS) (HR = 2.17, 95% CI:1.64-2.88) in cancer patients, without obvious heterogeneity. High AFAP1-AS1 expression also correlated with larger tumor size (odds ratio (OR) = 2.04, 95% CI: 1.54-2.72), advanced tumor stage (OR=2.35, 95% CI: 1.70-3.26), poor histological grade (OR =1.39, 95% CI: 1.02-1.90), lymph node metastasis (OR = 2.71, 95% CI: 1.98-3.72) and distant metastasis (OR = 2.96, 95% CI: 2.03-4.32). Thus high AFAP1-AS1 expression is predictive of poor OS, DFS, PFS, lymph node metastasis, distant metastasis, histological grade, larger tumor size and tumor stage, which suggests high AFAP1-AS1 expression may serve as a novel biomarker of poor prognosis in cancer.

Keywords: AFAP1-AS1; LncRNA; metastasis; neoplasms; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there is no conflicts of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1. Flowchart presented the steps of study selection in this meta-analysis
Figure 2
Figure 2. Forest plot showed the association between OS and AFAP1-AS1 expression level in cancer
Figure 3
Figure 3. Forest plot showed the association between DFS, PFS and AFAP1-AS1 expression level in cancer
Figure 4
Figure 4. Forest plot showed the association between tumor size and AFAP1-AS1 expression level in cancer
Figure 5
Figure 5. Forest plot showed the correlation between tumor stage and AFAP1-AS1 expression level in cancer
Figure 6
Figure 6. Forest plot of studies evaluated the correlation between histological grade and AFAP1-AS1 expression level in cancer
Figure 7
Figure 7. Forest plot of studies evaluated the correlation between lymph node metastasis and AFAP1-AS1 expression level in cancer
Figure 8
Figure 8. Forest plot of studies evaluated the relationship between distant metastasis and AFAP1-AS1 expression level in cancer
Figure 9
Figure 9. Funnel plot analysis of potential publication bias in survival and clinicopathological parameters group
(A) OS, (B) DPF + PFS, (C) tumor size, (D) tumor stage, (E) histological grade, (F) lymph node metastasis, (G) distant metastasis.
See this image and copyright information in PMC

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