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Book

Dysplastic Nevi

Dana Baigrie  1 , Laura S. Tanner
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Dysplastic Nevi

Dana Baigrie et al.
Free Books & Documents

Excerpt

A dysplastic nevus is also referred to as an atypical or Clark nevus and has been the topic of much debate in dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a “fried-egg” appearance, and are commonly biopsied by providers due to the concern for melanoma. A clinical diagnosis of atypical nevi is based upon the presence of at least 3 of the following features: diameter greater than 5 mm, ill-defined borders, irregular margins, and lesional color variation. Individuals with these nevi have an increased risk for melanoma, but contrary to some individual beliefs, these are considered banal nevi.

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Conflict of interest statement

Disclosure: Dana Baigrie declares no relevant financial relationships with ineligible companies.

Disclosure: Laura Tanner declares no relevant financial relationships with ineligible companies.

References

    1. Strazzulla LC, Li X, Zhu K, Okhovat JP, Lee SJ, Kim CC. Clinicopathologic, misdiagnosis, and survival differences between clinically amelanotic melanomas and pigmented melanomas. J Am Acad Dermatol. 2019 May;80(5):1292-1298. - PubMed
    1. de Unamuno Bustos B, Sahuquillo Torralba A, Moles Poveda P, Pérez Simó G, Simarro Farinos J, Llavador Ros M, Palanca Suela S, Botella Estrada R. Telomerase Expression in a Series of Melanocytic Neoplasms. Actas Dermosifiliogr (Engl Ed) 2019 Apr;110(3):212-219. - PubMed
    1. Salmi S, Siiskonen H, Sironen R, Tyynelä-Korhonen K, Hirschovits-Gerz B, Valkonen M, Auvinen P, Pasonen-Seppänen S. The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma. Melanoma Res. 2019 Jun;29(3):237-247. - PMC - PubMed
    1. Bsirini C, Smoller BR. Histologic mimics of malignant melanoma. Singapore Med J. 2018 Nov;59(11):602-607. - PMC - PubMed
    1. Colebatch AJ, Scolyer RA. Trajectories of premalignancy during the journey from melanocyte to melanoma. Pathology. 2018 Jan;50(1):16-23. - PubMed

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