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Book

Lisinopril

Edgardo Olvera Lopez  1 , Mayur Parmar  2 , Venkata Satish Pendela  3 , Jamie M. Terrell  4
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Lisinopril

Edgardo Olvera Lopez et al.

Excerpt

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that has been prescribed for nearly 30 years to manage hypertension and reduce cardiovascular strain. As a competitive ACE inhibitor, lisinopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This activity reviews lisinopril's mechanism of action, highlighting its distinct pharmacokinetic parameters and half-life compared to other ACE inhibitors. The discussion also includes lisinopril's FDA-approved indications, off-label uses, contraindications, drug-drug interactions, and potential toxicity. Additionally, dosage recommendations, warnings, and necessary patient monitoring protocols are outlined to support safe administration. This activity also emphasizes the critical role of an interprofessional healthcare team in managing hypertension with lisinopril.

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Conflict of interest statement

Disclosure: Edgardo Olvera Lopez declares no relevant financial relationships with ineligible companies.

Disclosure: Mayur Parmar declares no relevant financial relationships with ineligible companies.

Disclosure: Venkata Satish Pendela declares no relevant financial relationships with ineligible companies.

Disclosure: Jamie Terrell declares no relevant financial relationships with ineligible companies.

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