A critique on nuclear factor-kappa B and signal transducer and activator of transcription 3: The key transcription factors in periodontal pathogenesis

Abstract

Periodontal disease is initiated by microorganisms in dental plaque, and host immunoinflammatory response to the microbial challenge helps in disease progression. Conventional periodontal therapy was mainly targeted on the elimination of microbial component. However, a better understanding of molecular aspects in host response will enable the clinicians to formulate effective host modulation therapy (HMT) for the periodontal management. Inflammatory mediators were the main targets for HMT in the past. Transcription factors can regulate the production of multiple mediators simultaneously, and inhibition of these factors will be more beneficial than blocking individual molecule. Two important transcription factors implicated in chronic inflammatory diseases are nuclear factor kappa B (NF-κB) and signal transducers and activators of transcription 3. The role of these factors in periodontal disease is a less explored area. This comprehensive review is aimed at unveiling the critical role of NF-κB and signal transducers and activators of transcription 3 in periodontal pathogenesis. An online search was performed using MEDLINE/PubMed database. All publications till 2016 related to NF-κB, signal transducer and activator of transcription 3 (STAT3), and inflammation were included in writing this review. A total of 27,390 references were published based on the search terms used. Out of these, 507 were related to the periodontal research published in English till 2016. Relevant papers were chosen after carefully reading the abstract. This review has attempted to comprehend the existing knowledge regarding the role of transcription factors NF-κB and STAT3 in periodontal disease. Moreover, it also provides a connecting molecular link for the periodontal medicine concept.

Keywords: Host response; Signal Transducer and Activator of Transcription 3; inflammation; nuclear factor kappa B; periodontal disease; transcription factors.

Figure 1

Activation of nuclear factor kappa B and signal transducer and activator of transcription 3 and possible cross talk (indicated by dotted red arrow) in their signaling in periodontal disease. TLR – Toll like receptors, LPS – Lipopolysaccharide, JAK – Janus activated kinase, STAT3 – Signal signal transducer and activator of transcription 3, MYD88 – Myeloid differentiation primary response 88, IXB – its not X but kappa (κ)- the expansion is inhibitor kappa B, P50 – PROTEIN 50, P65 – PROTEIN 65, NFB – nuclear factor-kappa B