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Case Reports
. 2018 Jan;22(Suppl 1):S69-S72.
doi: 10.4103/jomfp.JOMFP_200_17.

Keratinizing pleomorphic adenoma: An unusual case report

Aanchal Tandon  1 , Rohit Jaiswal  1 , Safia Siddiqui  1 , Bharadwaj Bordoloi  1
Affiliations
Case Reports

Keratinizing pleomorphic adenoma: An unusual case report

Aanchal Tandon et al. J Oral Maxillofac Pathol. 2018 Jan.

Abstract

Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we report a case of slowly enlarging PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland in hard palate and discuss its microscopic features.

Keywords: Keratin; pleomorphic adenoma; squamous metaplasia.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Intraoral swelling on the palate having intact margins
Figure 2
Figure 2
Gross specimen measuring 1.5 cm × 1.5 cm × 1 cm
Figure 3
Figure 3
Histopathological image showing a well-circumscribed lesion composed of multiple cystic spaces (H&E, ×40)
Figure 4
Figure 4
Histopathological image showing tumor stroma showing large number of cystic spaces having keratotic lamellae and lined by squamous cells (H&E, ×200)
Figure 5
Figure 5
Histopathological image showing tumor stroma having numerous gland-like tubular structures (H&E, ×100)
Figure 6
Figure 6
Histopathological image showing tumor stroma showing tumor cells composed of basaloid, plasmacytoid and angular cells (H&E, ×400)
Figure 7
Figure 7
Histopathological image showing presence of mucous cells containing mucin (Periodic acid-Schiff stain, ×200)
See this image and copyright information in PMC

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