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. 2017 Dec;15(12):757-762.

In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT

Marzieh Aghahosseini  1 , Ashraf Aleyasin  1 , Fatemeh Sadat Sarfjoo  1 , Atossa Mahdavi  1 , Mansooreh Yaraghi  2 , Hojattollah Saeedabadi  3
Affiliations

In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT

Marzieh Aghahosseini et al. Int J Reprod Biomed. 2017 Dec.

Abstract

Background: The effect of elevated progesterone level on human chorionic gonadotropin (HCG) day in in vitro fertilization cycles is controversial. Some suppose that rise in progesterone level seems to have a negative impact on implantation and pregnancy by desynchronizing the endometrium, while others disagree.

Objective: To evaluate the superiority of the frozen cycle over fresh cycle on live birth in patients with elevated progesterone level on HCG day.

Materials and methods: In this double-blind, randomized clinical trial, 72 women undergoing assisted reproductive technology with elevated progesterone level (≥1.8 ng/dl) on HCG day were included. The participants were grouped by fresh versus frozen embryo transfer, randomly. Finally, the clinical pregnancy and live birth rate were compared.

Results: The implantation rate was 21.51%. The clinical pregnancy rate was 47.22% in fresh embryo transfer group (17/36) and 41.66% in frozen group (15/36) (p=0. 40). The live birth rate was not significantly difference between two groups (p=0.56).

Conclusion: None of the fresh and frozen cycles are superior to the other and we recommend individualizing the decision for each patient. The frozen cycle may impose more emotional stress on patients.

Keywords: Embryo transfer; Pregnancy; Progesterone.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Figure 1
Figure 1
Algorithm for patients and outcomes.
Figure 2
Figure 2
The relationship between age and the chance of pregnancy in women undergoing ART.
See this image and copyright information in PMC

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