Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May;23(3):347-362.
doi: 10.1007/s00775-018-1545-9. Epub 2018 Feb 28.

The role of zinc and its compounds in leukemia

Alexey P Orlov  1 , Marina A Orlova  2   3 , Tatiana P Trofimova  2   4 , Stepan N Kalmykov  2 , Dmitry A Kuznetsov  5
Affiliations
Review

The role of zinc and its compounds in leukemia

Alexey P Orlov et al. J Biol Inorg Chem. 2018 May.

Abstract

Zinc is one of the most important microelements necessary for normal body functioning. Zinc is marked in numerous diseases and, hence, its properties and behavior in the body have long been a subject of extensive study. This review considers trends in the assessment of the role of zinc and its compounds in the past decade. It becomes evident that redox-inactive zinc is the main supervisor in the conformation of the most important molecules in all body organs and tissues. We placed emphasis on the variety of zinc-binding sites and the role of zinc in the genesis and progress of different forms of leukemia. The importance of some families of transcription factors in the development and prognosis of treatment of various leukemia forms is examined; new directions of these studies are shown.

Keywords: Metallothioneins; Signaling pathway; Zinc; Zinc chelation; Zinc complexes; Zinc fingers; Zinc salicylates.

PubMed Disclaimer

References

    1. J Steroid Biochem Mol Biol. 2014 Mar;140:63-70 - PubMed
    1. Mol Aspects Med. 2005 Aug-Oct;26(4-5):245-55 - PubMed
    1. Cell Death Dis. 2014 Aug 28;5:e1399 - PubMed
    1. World J Biol Chem. 2011 Jun 26;2(6):140-5 - PubMed
    1. Nucleic Acids Res. 2011 Nov;39(21):9061-71 - PubMed

LinkOut - more resources