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Review
. 2018 Mar;56(3):154-162.
doi: 10.1007/s12275-018-7548-y. Epub 2018 Feb 28.

Intestinal microbiota and the immune system in metabolic diseases

Panida Sittipo  1 , Stefani Lobionda  1 , Yun Kyung Lee  2 , Craig L Maynard  3
Affiliations
Review

Intestinal microbiota and the immune system in metabolic diseases

Panida Sittipo et al. J Microbiol. 2018 Mar.

Abstract

The intestinal microbiota is comprised of millions of microorganisms that reside in the gastrointestinal tract and consistently interact with the host. Host factors such as diet and disease status affect the composition of the microbiota, while the microbiota itself produces metabolites that can further manipulate host physiology. Dysbiosis of the intestinal microbiota has been characterized in patients with certain metabolic diseases, some of which involve damage to the host intestinal epithelial barrier and alterations in the immune system. In this review, we will discuss the consequences of dietdependent bacterial dysbiosis in the gastrointestinal tract, and how the associated interaction with epithelial and immune cells impacts metabolic diseases.

Keywords: dysbiosis; immune system; intestinal barrier; intestinal microbiota; metabolic disease.

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