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Book

Hypoxia

Beenish S. Bhutta  1 , Faysal Alghoula  2 , Ilya Berim  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Hypoxia

Beenish S. Bhutta et al.
Free Books & Documents

Excerpt

Hypoxia occurs when oxygen is insufficient at the tissue level to maintain adequate homeostasis, stemming from various causes such as hypoventilation, ventilation-perfusion (V/Q) mismatch, or right-to-left shunting. This condition can arise from inadequate oxygen delivery to the tissues due to either low blood supply or low oxygen content in the blood, also known as hypoxemia.

Hypoxia can manifest across a spectrum of intensity, ranging from mild to severe, and present in acute, chronic, or mixed acute and chronic forms. The response to hypoxia varies among tissues—while some tissues can tolerate certain forms of hypoxia or ischemia for extended periods, others are significantly impaired by low oxygen levels.

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Conflict of interest statement

Disclosure: Beenish Bhutta declares no relevant financial relationships with ineligible companies.

Disclosure: Faysal Alghoula declares no relevant financial relationships with ineligible companies.

Disclosure: Ilya Berim declares no relevant financial relationships with ineligible companies.

References

    1. Hiraga T. Hypoxic Microenvironment and Metastatic Bone Disease. Int J Mol Sci. 2018 Nov 09;19(11) - PMC - PubMed
    1. Watts ER, Walmsley SR. Inflammation and Hypoxia: HIF and PHD Isoform Selectivity. Trends Mol Med. 2019 Jan;25(1):33-46. - PubMed
    1. Keuski BM. Updates in diving medicine: evidence published in 2017-2018. Undersea Hyperb Med. 2018 Sep-Oct;45:511-520. - PubMed
    1. Gaspar JM, Velloso LA. Hypoxia Inducible Factor as a Central Regulator of Metabolism - Implications for the Development of Obesity. Front Neurosci. 2018;12:813. - PMC - PubMed
    1. Mesarwi OA, Loomba R, Malhotra A. Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease. Am J Respir Crit Care Med. 2019 Apr 01;199(7):830-841. - PMC - PubMed

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