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Heparin-induced thrombocytopenia (HIT) is a severe complication that can occur in patients exposed to any form or amount of heparin products. A fall in platelet counts and a hypercoagulable state characterize HIT. Patients who experience HIT may also develop thromboembolic complications that are associated with morbidity and mortality. This is a significant burden since heparin is widely used for treatment and prophylaxis of thromboembolism, line flushes, and heparin-coated catheters. This review will discuss the pathophysiology, diagnosis, and management of patients with HIT.
Hogan M, Berger JS. Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management. Vasc Med. 2020 Apr;25(2):160-173.
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Nonaka T, Harada M, Sumi M, Ishii W, Ichikawa T, Kobayashi M. A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Case Rep Rheumatol. 2019;2019:2724304.
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Bloom MB, Johnson J, Volod O, Lee EY, White T, Margulies DR. Improved prediction of HIT in the SICU using an improved model of the Warkentin 4-T system: 3-T. Am J Surg. 2020 Jan;219(1):54-57.
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Gallo T, Curry SC, Padilla-Jones A, Heise CW, Ramos KS, Woosley RL, Raschke RA. A computerized scoring system to improve assessment of heparin-induced thrombocytopenia risk. J Thromb Haemost. 2019 Feb;17(2):383-388.
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