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Hyaluronic acid is a high-molecular-weight polysaccharide, which is widely distributed in the connective tissue extracellular matrix. Several hyaluronic acid preparations have become widely available for subcutaneous/intradermal, intraarticular, topical, and ocular use. This activity outlines the indications, mechanism of action, administration, significant adverse effects, and contraindications of various hyaluronic acid preparations to increase practitioners' knowledge regarding how to approach this substance and use it in practice for its indicated purposes.
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Alharbi M. Review of sterility of reused stored dermal filler. J Cosmet Dermatol. 2019 Oct;18(5):1202-1205.
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Charlesworth J, Fitzpatrick J, Perera NKP, Orchard J. Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee. BMC Musculoskelet Disord. 2019 Apr 09;20(1):151.
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Kim JH, Moon MJ, Kim DY, Heo SH, Jeong YY. Hyaluronic Acid-Based Nanomaterials for Cancer Therapy. Polymers (Basel) 2018 Oct 12;10(10)
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Fallacara A, Baldini E, Manfredini S, Vertuani S. Hyaluronic Acid in the Third Millennium. Polymers (Basel) 2018 Jun 25;10(7)
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