Methylphenidate
- PMID: 29494058
- Bookshelf ID: NBK482451
Methylphenidate
Excerpt
Methylphenidate is FDA-approved for the treatment of ADHD in adults and children 6 years and older. Additionally, methylphenidate serves as a second-line therapy for narcolepsy in adults. Off-label uses include cancer-related fatigue, refractory depression in older adults, apathy in patients with Alzheimer disease, and cognitive enhancement (eg, memory improvement); the efficacy of methylphenidate for these conditions is moderate at best.
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References
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- Theleritis C, Siarkos K, Katirtzoglou E, Politis A. Pharmacological and Nonpharmacological Treatment for Apathy in Alzheimer Disease : A systematic review across modalities. J Geriatr Psychiatry Neurol. 2017 Jan;30(1):26-49. - PubMed
-
- Escalante CP, Meyers C, Reuben JM, Wang X, Qiao W, Manzullo E, Alvarez RH, Morrow PK, Gonzalez-Angulo AM, Wang XS, Mendoza T, Liu W, Holmes H, Hwang J, Pisters K, Overman M, Cleeland C. A randomized, double-blind, 2-period, placebo-controlled crossover trial of a sustained-release methylphenidate in the treatment of fatigue in cancer patients. Cancer J. 2014 Jan-Feb;20(1):8-14. - PMC - PubMed
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- Rojí R, Centeno C. The use of methylphenidate to relieve fatigue. Curr Opin Support Palliat Care. 2017 Dec;11(4):299-305. - PubMed
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