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Book

Intraepidermal Carcinoma

Ahmad Charifa  1 , Keith Volner  2 , Amanda M. Oakley  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Intraepidermal Carcinoma

Ahmad Charifa et al.
Free Books & Documents

Excerpt

“Intraepidermal” means that the cancerous cells are located in the epidermis from where they originally developed (in situ). Squamous cell carcinoma in situ (SCCIS) is a vitiated, superficial growth of cancerous cells on the skin’s outer layer. It is not a severe condition but could develop into a full form of invasive skin cancer if not detected early or well managed. It is also known as carcinoma in situ in the literature or as Bowen disease after John T. Bowen, an American dermatologist who first described the condition in 1912. Flat cells, known as squamous cells, are located in the epidermis. They are responsible for the production of the keratin protein and affected by this condition.

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Conflict of interest statement

Disclosure: Ahmad Charifa declares no relevant financial relationships with ineligible companies.

Disclosure: Keith Volner declares no relevant financial relationships with ineligible companies.

Disclosure: Amanda Oakley declares no relevant financial relationships with ineligible companies.

References

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    1. Fernández-Sánchez M, Charli-Joseph Y, Domínguez-Cherit J, Guzman-Herrera S, Reyes-Terán G. Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases. Indian J Dermatol. 2018 Nov-Dec;63(6):506-508. - PMC - PubMed
    1. Wozniak-Rito AM, Rudnicka L. Bowen's Disease in Dermoscopy. Acta Dermatovenerol Croat. 2018 Jun;26(2):157-161. - PubMed
    1. Jiyad Z, O'Rourke P, Soyer HP, Green AC. Clinical comparison of actinic changes preceding squamous cell carcinoma vs. intraepidermal carcinoma in renal transplant recipients. Clin Exp Dermatol. 2017 Dec;42(8):895-897. - PubMed
    1. Fernandez Figueras MT. From actinic keratosis to squamous cell carcinoma: pathophysiology revisited. J Eur Acad Dermatol Venereol. 2017 Mar;31 Suppl 2:5-7. - PubMed

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