Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis
- PMID: 29495538
- PMCID: PMC5877535
- DOI: 10.3390/ijms19030674
Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis
Abstract
Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven't discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.
Keywords: articular cartilage; molecular pathology; osteoarthritis (OA); therapeutics.
Conflict of interest statement
The authors declare no conflict of interest.
References
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