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Review
. 2018 Feb 27;19(3):674.
doi: 10.3390/ijms19030674.

Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Affiliations
Review

Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Ju-Ryoung Kim et al. Int J Mol Sci. .

Abstract

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven't discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.

Keywords: articular cartilage; molecular pathology; osteoarthritis (OA); therapeutics.

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Conflict of interest statement

The authors declare no conflict of interest.

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