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Review
. 2018 Feb 28;10(3):101.
doi: 10.3390/v10030101.

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

Jonas D Albarnaz  1 , Alice A Torres  2 , Geoffrey L Smith  3
Affiliations
Review

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

Jonas D Albarnaz et al. Viruses. .

Abstract

The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.

Keywords: genetic engineering; immune evasion; immunological memory; orthopoxviruses; smallpox; vaccine; vaccinia virus.

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Conflict of interest statement

The authors declare no conflict of interest.

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